I don't know why you're trying to run XDRE under Wine instead of compiling it.
That's what I need to do in order to compile and run it on Arch:
sudo pacman -S git sdl2 wxgtk3
git clone https://notabug.org/38_ViTa_38/xdre.git
cd xdre
./bootstrap
CFLAGS=-Wl,--allow-multiple-definiton ./configure
make -j4
src/xdre